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- W2386771569 abstract "AIM: To study the effects of bombesin on thermoregulation and its relationship with camp content at 4 ℃ . METHODS: Bombesin and IL-1β were microinjected into the lateral ventricles (LV) of male SD rats. Changes in colonic temperature and content of cAMP in hypothalamus and plasma were measured. RESULTS: (1)In the febrile rats induced by i.c.v. injection of IL-1β, content of cAMP in hypothalamus and plasma increased (P 0.01 ). (2) Bombesin could lower normal body temperature in rats. Content of cAMP in hypothalamus was lower than that in the control group (P 0.01 ). (3) Fever induced by IL-1β was reversed by pretreatment with bombesin, and content of cAMP in hypothalamus was decreased compared with that in control group (P 0.01 ). CONCLUSION: Bombesin can inhibit IL-1β-induced fever at 4 ℃ , and the mechanism may be related to the inhibition the synthesis and release of cAMP." @default.
- W2386771569 created "2016-06-24" @default.
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- W2386771569 date "2005-01-01" @default.
- W2386771569 modified "2023-09-27" @default.
- W2386771569 title "Effects of bombesin on cAMP content of hypothalamus and plasma in IL-1β-induced fever rats under lower temperature" @default.
- W2386771569 hasPublicationYear "2005" @default.
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