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- W2386773722 abstract "Objective To explore the safety of human hypoxia inducible factor-1α (HIF-1α) for the rabbit model of acute hindlimb ischemia.Methods Adenovirus- mediated HIF-1α(Ad-HIF-1α) and adenovirus- mediated blank genes (Ad-Blank) were amplified and adenoviral titer was determined.A rabbit model of acute ischemic hindlimb was established and the rabbits were randomized to receive an injection of Ad- HIF-1α of 2.0×1010 PFU,Ad-Blank of 2.0×1010 PFU,or normal saline (NS) of 0.5mL into the muscle group without blood supply from femoral artery.ECG,blood test,and liver and renal function tests were performed before the procedure and on days 7 and 28.All the rabbits were observed pathologically on day 28.Results The titre of Ad-HIF-1α was 2.0 × 1013 Pfu / mL,and that of Ad-Blank was 1.5 × 1013 Pfu / mL.Blood parameters and liver and kidney function were within the normal ranges in the three goups and there were no significant differences in those tests (P 0.05).ECG was normal.No cancer cells were seen in the rabbits receiving Ad- HIF-1α.Conclusions There are no significant adverse reactions in the rabbits with hindlimb ischemia receiving Ad-HIF- 1α at a single dose of 2.0 × 1010 PFU.Ad-HIF-1α is relatively safe." @default.
- W2386773722 created "2016-06-24" @default.
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- W2386773722 date "2010-01-01" @default.
- W2386773722 modified "2023-09-25" @default.
- W2386773722 title "The safety of adenovirus-mediated hypoxia inducible factor- 1αfor rabbit hindlimb ischemia" @default.
- W2386773722 hasPublicationYear "2010" @default.
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