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- W2386795703 abstract "AIM To validate the differential gene expression profile of 185 target genes selected from a preliminary microarray study. METHODS The relative mRNA level in two groups of cell samples, ie, 0.5 μmol·L~ -1 benzo(a)pyrene 7,8-dihydrodiol 9,10-epoxide (BPDE) and 0.1% DMSO solvent treated, respectively, was evaluated by a high-throughput quantitative real-time RT-PCR approach based on the TaqMan~ Low Density Array (Applied Biosystems). RESULTS The total of 51 genes (12 up-regulated and 39 down-regulated) related to cellular proliferation, differentiation, apoptosis, transcriptional regulation and metabolism etc were detected differentially expressed (n=3, P0.05). CONCLUSION High throughput quantitative real-time RT-PCR is a timesaving technique for validating the data obtained from microarray experiments. The validating results indicate that the activation of multiple signaling pathways and alteration of gene expression are responsible for the cell cycle arrest and metabolic alteration induced by BPDE exposure." @default.
- W2386795703 created "2016-06-24" @default.
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- W2386795703 date "2007-01-01" @default.
- W2386795703 modified "2023-09-25" @default.
- W2386795703 title "Differential gene expression profiles in benzo(a)pyrene 7,8-dihydrodiol 9,10-epoxide-treated FL cells validated by high-throughput quantitative RT-PCR assay" @default.
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