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- W2386820594 abstract "[Purpose] To explore expression and significance of ER, c-myc and hTERT in benign and malignant breast lesions. [Methods] Expression of ER, c-myc and hTERT was detected by immunohistochemical method (SP method) in 25 cases with breast adenosis and 79 cases with breast carcinoma. [Results] The positive expression of ER, c-myc and hTERT in breast adenosis was 28.0%, 12.0% and 20.0% respectively; and that in breast carcinoma, 72.2%, 70.1% and 92.4% respectively, with significant difference between benign and malignancy(P0.01). Expressions between c-myc and hTERT; ER and hTERT; and ER and c-myc showed positive correlation (r=0.382, 0.388 and 0.632 respectively, P0.01) in breast carcinoma; but the expression of hTERT was not correlated with age, tumor size and lymph node metastasis(P0.05) in breast carcinoma. [Conclusion] High expression of ER, c-myc and hTERT is found. The high expression may be involved in carcinogenesis and progress in breast carcinoma. High expression of ER and c-myc may correlate with transcription activation of hTERT and telomerase activation in carcinogenesis of breast cancer." @default.
- W2386820594 created "2016-06-24" @default.
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- W2386820594 date "2007-01-01" @default.
- W2386820594 modified "2023-09-23" @default.
- W2386820594 title "Expression of ER, c-myc and hTERT in Benign and Malignant Breast Lesions" @default.
- W2386820594 hasPublicationYear "2007" @default.
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