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- W2386824401 abstract "Objective To study the association between the plasma homocysteine levels and coronary heart disease(CHD) and the associations of methionine synthase recuctase (MTRR) A66G polymorphisms, folate, VitB12 and plasma homocysteine levels with CHD. Methods 190 CHD patients documented by coronary angio-gram and 100 patients with normal angiographic results were included in this study. Plasma homocysteine,folate and VitB12 levels were measured. The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was used to analyse the MTRR A66G genotypes. Results The plasma homocysteine levels were significantly higher in CHD group than in the cont(?)ol group( 16.8±8.8 vs 12.9±6.3μmol/L, P = 0.002). Both the folate and VitB12 levels were negatively correlated to the plasma homocysteine level, but were not correlated to CHD. The differences of the plasma homocysteine levels among the MTRR 66GG, AG and AA genotypes were not statistically significant ( P = 0. 908). There was no significant difference in the prevalence of the MTRR A66G genotypes between CHD group and the control group ( P = 0.198). Conclusion The plasma homocysteine level in coronary heart disease patients was increased. The plasma folate and vitamine12 levels were negatively correlated to plasma homocysteine and MTRR A66G genotypes are not related to plasma homocysteine level and presence of coronary heart disease." @default.
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- W2386824401 date "2004-01-01" @default.
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- W2386824401 title "The study of association between plasma homocysteine level and coronary heart disease" @default.
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