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- W2386835148 abstract "Objective: To explore the role of miR-188-5p on the expression of matrixmetallo- proteinases 13(MMPs-13) during renal interstitial fibrosis in mice. Methods: Mice renal mesangial cells(MC) were treated with TGF-β1 at concentration of 2ng/ml for 24h, then the mRNA and protein level of miR-188-5p and MMP-13 were tested. Next, reporter gene experiment was used to verify the effect of miR-188-5p on the regulation of MMP-13. In order to observe the effect on MMP-13, level of miR-188-5p in MC cell were then up/down regulated by mimics/inhibitor through Lipofectamine transfection. Results: TGF-β1 increased the expression of the miR-188-5p, while the mRNA and protein level of MMP-13 were reduced. Reporter gene experiment confirmed the negative regulation of miR-188-5p on MMP-13 expression. Up-regulation of miR-188-5p could inhibit the expression of MMP-13, while down-regulation of miR-188-5p could increade the level of MMP-13. Conclusion: In renal interstitial fibrosis, miR-188-5p may play a fibrogenic role by down-regulating the expression of MMP-13. This study provided a new therapeutic target for renal interstitial fibrosis." @default.
- W2386835148 created "2016-06-24" @default.
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- W2386835148 date "2014-01-01" @default.
- W2386835148 modified "2023-09-25" @default.
- W2386835148 title "Effect of miR-188-5p on the Expression of MMP-13 During Renal Interstitial Fibrosis in Mice" @default.
- W2386835148 hasPublicationYear "2014" @default.
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