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- W2386845993 abstract "Objective To discuss the impacts of total Panax notoginseng saponin(TPNS) on the cell cycle-related protein in the proliferation of vascular smooth muscle cells(VSMCs) proliferating model induced by platelet-derived growth factor(PDGF).Methods A VSMC proliferating model was established induced by PDGF-BB and the effects of rat plasma containing drugs on the VSMC proliferation were observed.The expressions of proliferating cell nuclear antigen(PCNA) and cell cycle-related proteins were determined with flow cytometry.Results After being stimulated by PDGF,up-regulation of PCNA,cyclinD1,cyclin-dependent kinase-4(CDK4) and down-regulation of p21 protein in VSMCs were observed.These changes were inhibited by atorvastatin and TPNS drug-containing plasma,and these effects in both groups were not significant(P0.05).Conclusion PDGF can promote cell cycle conversion and quicken proliferation of VSMCs.Atorvastatin and TPNS maybe inhibit effectively the VSMC proliferation induced by PDGF with suppressing the expression of cell cycle-related proteins." @default.
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- W2386845993 date "2012-01-01" @default.
- W2386845993 modified "2023-09-25" @default.
- W2386845993 title "Effects of total Panax notoginseng saponins on the expression of cell cycle-related proteins of rat vascular smooth muscle cells proliferation model" @default.
- W2386845993 hasPublicationYear "2012" @default.
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