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- W2386846658 abstract "Objective To explore the effect of chronic low lead exposure on molecular pathological mechanisms of learning and memory of rats at the developmental stage Methods The changes of N methyl D aspartate receptor 1 (NMDAR 1) mRNA expression in rat hippocampus were observed by using digoxigenin labled anti sense oligonucleotide probes in situ hybridization technique Results The changes in NMDAR 1 mRNA levels in Pb exposed rat hippocampus were found to be dependent upon the developmental period of exposure and the region of the hippocampus analyzed Hippocampal NMDAR 1 mRNA levels increased significantly in the CA1 (18 75%) and CA3 (13 2%) ( P 0 05) pyramidal cells from 16 day old Pb exposed rats, but dentate gyrus NMDAR 1 mRNA decreased by 14 29% at the same same time ( P 0 01) At 32nd day and 64th day, no changes were found except for a DG decrease of 9 67%, 10 67%( P 0 01) Conclusion NMDAR 1 mRNA expression in developing rats is altered by chronic low lead exposure, which might be a molecular mechanism for the persistent cognitive deficits that result from developmental exposure to Pb 2+" @default.
- W2386846658 created "2016-06-24" @default.
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- W2386846658 date "2003-01-01" @default.
- W2386846658 modified "2023-09-23" @default.
- W2386846658 title "Effects of chronic low lead exposure on NMDA receptor subunit 1 mRNA in hippocampus in rats at the developmental stage" @default.
- W2386846658 hasPublicationYear "2003" @default.
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