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- W23868495 endingPage "69" @default.
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- W23868495 abstract "Addiction science largely has individual behavior as its focus, albeit at increasingly differentiated levels of analysis, ranging from behavior to brain to genes. Context is rarely brought into the causal matrix, although without the addictive object, addiction could not occur. Moreover, although the emergence of addiction is a developmental process, developmental changes in these relationships are rarely examined. Findings that address these issues are reported from a 28-year-long prospective high risk for alcoholism family study, the Michigan Longitudinal Study, which was designed to evaluate these cross-development linkages from early childhood to early adulthood, across multiple levels of analysis involving genes, neural circuitry, behavior, and social context. Analyses focus on the network of GABA2 relationships with externalizing behavior and with nucleus accumbens responsivity, as they relate to problems of alcohol use over the course of adolescence. They illustrate the moderating effect of social relationships—but only in specific portions of adolescence." @default.
- W23868495 created "2016-06-24" @default.
- W23868495 creator A5070368893 @default.
- W23868495 date "2014-01-01" @default.
- W23868495 modified "2023-10-18" @default.
- W23868495 title "Genes, Brain, Behavior, and Context: The Developmental Matrix of Addictive Behavior" @default.
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- W23868495 doi "https://doi.org/10.1007/978-1-4939-0653-6_4" @default.
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