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- W2386856653 abstract "Objective To investigate the effects of protein kinase C (PKC), intracellular Ca + on cardiomyocyte protection of hypoxic preconditioning (PC). Methods The cell viability, LDH release, and the content of MDA and SOD were measured in the models of hypoxia/reoxygenation (H/R) of cultured neonatal rat cardiomyocytes, with and without pretreat-ment of Chelerythrine, and BAPTA/AM. Results Hypoxic PC attenuated cardiomyocyte injury induced by H/R. Pretreatment with PKC ininbitor - chelery-thrine or the intracellular Ca2+ chelator - BAPTA/AM abolished the protection effect of hypoxic PC. Conclusion The PKC and intracellular Ca2+ may be involved in the protection mechanism of PC." @default.
- W2386856653 created "2016-06-24" @default.
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- W2386856653 date "2002-01-01" @default.
- W2386856653 modified "2023-09-28" @default.
- W2386856653 title "Effects of protein kinase C, intracellular Ca~(2+) on cardiomyocytes protection of hypoxic preconditioning" @default.
- W2386856653 hasPublicationYear "2002" @default.
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