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- W2386857734 abstract "Objective To investigate the prophylactic role of early nasal continuous positive airway pressure(nCPAP)on respiratory distress syndrome(RDS)in the extremely low birth weight infants of 28-32 gestational weeks.Methods A total of 72 eligible infants of 28-32 gestational weeks were randomly allocated to prophylactic(observe group)or therapeutic(control group)nCPAP.Prophylactic nCPAP was started within 30 minutes of birth,irrespective of oxygen requirement and clinical status.Therapeutic nCPAP was started when FiO2 requirement was 0.4,for more than 30 minutes,to maintain transcutaneous oxygen saturation between 93% and 96%.Exogenous surfactant was given when FiO2 requirement was 0.4 in nCPAP in the presence of radiological signs of respiratory distress syndrome.Observe the incidence of RDS and the administration of exogenous surfactant(PS)and mechanical ventilation as well.Results The incidence of RDS in observe group was significatly lower than that of control group(45.0% vs 68.8%,P0.05),and the incidence of gradeⅠ～Ⅱ RDS in observe group was significantly lower than that of control group(P0.05),but the incidence of grade Ⅲ～Ⅳ RDS was not significantly difference between two groups(P0.05).However,that the need for surfactant was 25% in observe group and 50% in control group(P0.05).The need of mechanical ventilation in first 72 hours of life in observe group was significatly lower than that of control group(47.5% vs 71.9%,P0.05).While no significant difference at the incidence of intracranial hemorrhage was found(P0.05).Conclusion nCPAP is a non invasive method with benefits in the treatment of the RDS in preterm newborn of 28-32 gestational weeks.Using early nCPAP may have some benefits as prophylaxis for RDS and reduce the necessity for surfactant and mechanical ventilation." @default.
- W2386857734 created "2016-06-24" @default.
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- W2386857734 date "2009-01-01" @default.
- W2386857734 modified "2023-09-24" @default.
- W2386857734 title "The application of prophylactic nasal continuous airway positive pressure on respiratory distress syndrome in preterm newborns of 28-32 gestational weeks" @default.
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