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- W2386873941 abstract "Objective To analyze the status and distribution of human papillomavirus(HPV) in women patients with cervical cancer in the coastal areas of Guangxi,and to investigate the relationship between HPV infection and cervical lesions.Methods According to pathological examination,164 patients with cervical lesions who were positive for HPV-DNA were divided into three groups:chronic inflammatory group(n=22),cervical intraepithelial neoplasia group(CIN Ⅰ-Ⅲ,n=73) and cervical cancer group(n=69).The exfoliated cells were collected and HPV genotypes were detected by diagnostic PCR to analyze the status and distribution of HPV in all patients.Results Besides a low-risk type HPV 42,20 of 21 subtypes were detected.A total of 117(71.3%) of 164 HPV-positive patients had a single infection,whereas 47 patients(28.7%) had multiple HPV types.The positive rate was 13.4% in chronic inflammatory group,and the common HPV genotypes were 16,52,58,18,33 and 53.The positive rate was 44.5% in cervical intraepithelial neoplasia group,and the common HPV genotypes were 16,18,33,52,58 and 31.The positive rate was 42.1% in cervical cancer group,and the common HPV genotypes were 16,18,33,31,58 and 52.Conclusion HPV-positive patients with cervical cancer in the coastal areas of Guangxi were infected mainly with HPV genotypes 16 and 18,and secondly with genotypes 33,52,58 and 31.Thus,HPV-DNA testing provides important theoretical basis for vaccine development and cervical cancer screening,diagnosis and prognosis evaluation." @default.
- W2386873941 created "2016-06-24" @default.
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- W2386873941 date "2010-01-01" @default.
- W2386873941 modified "2023-09-26" @default.
- W2386873941 title "Human Papillomavirus Genotypes in Women with Cervical Cancer in Coastal Areas of Guangxi" @default.
- W2386873941 hasPublicationYear "2010" @default.
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