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- W2386875504 abstract "Objective:To correlatively study the relationship between the water diffusion parameters measured using diffusion tensor imaging (DTI) and the histological malignancy of astrocytoma.Methods:DTI was pre-operatively performed using a Siemens Trio MR scanner in 43 cases of patients with histologically proven astrocytoma.Mean diffusivity (MD),fractional anisotropy (FA) and diffusion weighted imaging (DWI) maps were proceeded and created using the workstation of Leonardo Syngo 2004A,Siemens.All the parameter maps were co-registered.The high signal intensity zone demonstrated on the DTI image was regarded as the zone of tumor parenchyma,then,the parameter values (MD,FA and DWI) of ROI in tumor parenchyma and those in the corresponding white matter zone of the contralateral normal hemisphere were individually measured.The relative MD (rMD) and relative FA (rFA) were calculated (parameter value of the tumor/that of the white matter in the contralateral normal hemisphere).Statistically and pre-operatively,with the use of variance analysis (single factor) and LSD test,the rMD and rFA were individually compared,and,the correlation in the differences of rMD and rFA with different pathological gradings of astrocytoma in reference to the WHO classification criteria was explored.Results:In our collection of 43 cases of astrocytomas,there were 19 cases of astrocytoma (WHO Ⅱ),12 cases of anaplastic astrocytoma (WHO Ⅲ) and 12 cases of glioblastoma multiforme (WHO Ⅳ).The rMD values of WHO Ⅳ (1.220±0.227) astrocytoma were significantly lower than those of the WHO Ⅲ(1.599±0.416) and WHO Ⅱ(2.264±0.565) astrocytomas (P=0.015 and P0.001 respectively).The rMD values of the WHO Ⅲ astrocytoma were significantly lower than those of the WHO Ⅱ astrocytoma (P0.001).The rFA values of the WHO Ⅳ astrocytoma were significantly higher than those of the WHO Ⅲ (0.333±0.100) and WHO Ⅱ astrocytomas (0.268±0.090) (P=0.015 and P0.001,respectively).There was no significance of the rFA between the WHO Ⅲ and WHO Ⅱ astrocytomas.Conclusion:Referring to the rMD and rFA values measured from the pre-operative DTI,the prediction of different pathological gradings of astrocytoma was feasible and possible,and the therapeutic treatments and the guidance of stereostatic biopsy sampling site selection for the tumors would thus have been optimized as well." @default.
- W2386875504 created "2016-06-24" @default.
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- W2386875504 date "2007-01-01" @default.
- W2386875504 modified "2023-09-24" @default.
- W2386875504 title "Application of Diffusion Tensor Imaging on Preoperative Grading of Astrocytoma" @default.
- W2386875504 hasPublicationYear "2007" @default.
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