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- W2386880212 abstract "A rapid and sensitive liquid chromatography/tandem mass spectrometry(LC/MS) method has been developed and validated for simultaneous quantification of risperidone and its major active metabolite 9-hydroxyrisperidone in Beagle plasma.Clozapine is used as internal standard for risperidone and 9-hydroxyrisperidone.The analytes are extracted from Beagle plasma using liquid-liquid extraction.The analytes are separated on an Agilent eclipse XDB C18(150mm×4.6mm I.D.,5μm) column using mobile phase of acetonitrile/water(pH adjusted to 4.6 with acetic acid and 10 mmol·L-1 ammonium acetate) with gradient elution.The mass transition ion-pair is followed as m/z 411.4→191.0 for risperidone and m/z 427.2→207.2 for 9-hydroxyrisperidone.The linear concentration range of the calibration curve is 0.05-100 ng·mL-1,and with a lower limit of quantification is 0.05 ng·mL-1 for both risperidone and 9-hydroxyrisperidone.The intra-and inter-day precision is less than 7.8%.The accuracy is within ±8.7%.The method is applied for the determination of risperidone and 9-hydroxyrisperidone in plasma of Beagle dogs which have been i.m.administrated risperidone microsphere." @default.
- W2386880212 created "2016-06-24" @default.
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- W2386880212 date "2008-01-01" @default.
- W2386880212 modified "2023-09-27" @default.
- W2386880212 title "Determination of Risperidone and 9-Hydroxyrisperidone in Beagle Plasma by LC/MS" @default.
- W2386880212 hasPublicationYear "2008" @default.
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