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- W2386902016 abstract "Objective To explore the effects of phoxim on the spermatogenic cell in male mice.Methods 48 health Kunming male mice were randomly divided into six groups(four different dose of phoxim groups、negative control group and positive control group).All the mice including negative and positive control groups were treated with respective solution by peritoneal injection.The mice were killed on day 35 to observe the changes of the weight of body and testis and epididymis、sperm production、sperm motility and the abnormal sperm、the frequency of micronuclei in bone marrow cell.Results The male mice exposed to phoxim at higher doses [11.69、23.38 and 46.75mg/(kg·bw)] showed significant reduction of sperm production as compared with the negative control((P0.01).) There was a significant decrease of sperm motility rate in the groups exposed to phoxim(P(0.05)).Meanwhile the frequency of abnormal sperm and micronuclei in the groups exposed to phoxim was increased significantly(P0.05).Conclusion The result showed that phoxim had toxic effect on the genital system of male mice and mainly induced a reduction of sperm production and sperm motility rate and an increase of abnormal sperm.And phoxim also had mutagenesis in mice." @default.
- W2386902016 created "2016-06-24" @default.
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- W2386902016 date "2006-01-01" @default.
- W2386902016 modified "2023-09-25" @default.
- W2386902016 title "Studies on the Effects of Phoxim on the Quality of Spermatogenic Cell in Mice" @default.
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