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- W2386908266 abstract "Objective:To observe the effect of electroacupuncture on knee joint chondrocyte apoptosis in rabbits with knee osteoarthritis(KOA),and to explore the mechanisms of electroacupuncture on KOA.Methods:Thirty healthy New Zealand white rabbits were randomly divided into 3 groups as normal control group,model control group and electroacupuncture group,10 cases in each group.Left knee joints of experimental rabbits in model control group and electroacupuncture group were all built models through Hulth method.At the 5th week after modeling,cases in electroacupuncture group were administrated with electroacupuncture,while the others in the normal control group and model control group were administrated with normal feeding without treatment.After 4 weeks of treatment,all of the experimental rabbits were executed for making slices of left femoral condyle which were observed on the morphous of cartilaginous tissue and chondrocyte apoptosis situation.Results:①The morphous of cartilaginous tissue:the situations as smooth cartilage surface,clearness in four-layer structure,evenly distribution of chondrocytes without clustering and complete tidemark were found in normal control group;the situations as decrease in articular cartilage thickness,rough surface,significant fibrosis and fissures,clustered chondrocytes and fractured tidemark were found in model control group;and the situations as decrease in articular cartilage thickness,unsmooth surface,rare fibrosis and fissures,clustered chondrocytes and fractured tidemark were found in electroacupuncture group.②Chondrocyte apoptosis situation:there were statistical difference in chondrocyte apoptosis rate of experimental rabbits among the 3 groups(F=126.753,P=0.000).Chondrocyte apoptosis rate of model control group was higher than that of normal control group and electroacupuncture group respectively(LSD-t=3.769,P=0.000;LSD-t=7.000,P=0.000),and the chondrocyte apoptosis rate of electroacupuncture group was higher than that of normal control group(LSD-t=10.769,P=0.000).Conclusion:Electroacupuncture can relieve articular cartilage injuries of KOA through inhibiting chondrocyte apoptosis,which may be one of the mechanisms of electroacupuncture on KOA." @default.
- W2386908266 created "2016-06-24" @default.
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- W2386908266 date "2012-01-01" @default.
- W2386908266 modified "2023-09-28" @default.
- W2386908266 title "Study on the effect of electroacupuncture on knee joint chondrocyte apoptosis in rabbits with knee osteoarthritis" @default.
- W2386908266 hasPublicationYear "2012" @default.
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