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- W2386927320 abstract "Objective:To investigate the variation and value of renin-angiotensin system (RAS) in patients with septic shock.Methods:We studied 21 patients with septic shock and 24 patients with non-septic shock, assessed all patients with APACHE II score system and the Sequential Organ Failure Assessment (SOFA) system. Furthermore, all patients were divided into two groups(survival vs dead) by prognosis .Plasma renin activity (PRA) and angiotensin (Ang) II concentration in serum was assayed using a commercial radioimmune assay (RIA) kit. A Pearson correlation coefficient was calculated to compare linear relationships between PRA ,AngⅡ and APACHEⅡs,SOFAs,and LAC.Results:Compared with non-septic shock group , PRA and AngⅡ were significantly elevated in group with septic shock.The mortality,APACHEⅡscores, SOFA scores ,and LAC in septic group was higher than the non-septic group. Compared with survival group , PRA and AngⅡ were significantly elevated in dead group. PRA was found a positive correlation with APACHEⅡs,SOFAs,and LAC(r=0.409、0.601 and 0.671), AngⅡ was also found a positive correlation with APACHEⅡs ,SOFAs ,and LAC (r=0.491,0.776 and 0.690).Conclusion:RAS is activated in septic shock , PRA and Ang II concentration in serum were Elevated,PRA and Ang II concentration correlate with organ failure and severity in patients with septic shock." @default.
- W2386927320 created "2016-06-24" @default.
- W2386927320 creator A5018748509 @default.
- W2386927320 date "2013-01-01" @default.
- W2386927320 modified "2023-09-23" @default.
- W2386927320 title "Renin-angiotensin System Activation Correlates with Organ Failure and Severity in Patients with Septic Shock" @default.
- W2386927320 hasPublicationYear "2013" @default.
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