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• W2386944738 abstract "[Objective] To establish a mutine model for allogeneic umbilical cord blood transplantation by intra-bone marrow injection, investigate its effects on the homing and engraftment of HSCs, hematopoietie and immunological reconstruction and GVHD of recipient mice after transplantation. [Methods] BALB/C recipient mice conditioned with sublethal dose ~(60)Co γ-ray radiotherapy were transplanted with FNPB from C57BL/6 mice by intrabone marrow injection or via the tail vein. Two hundred recipient mice were divided into four groups at random: intrabone marrow injection group (IBM group), intravenous injection group (Ⅳ group), irradiated control group, normal group. There were 50 recipient mice in every, group. The distribution of CFSE-labeled FNPB inside the recipients was observed in frozen sections of different organs or by flow cytometry. The survival rate, engraftment level, recovery of hematopoietie and immunological function and GVHD of recipient mice were studied. [Results] (1) Tracing of the CFSE-labeled FNPB showed that by 72 hours after infusion the IBM-injected FNPB mainly accumulated in the BM cavity of the injected side tibia and few was trapped in the lung, but the amount of FNPB inside the noninjected side tibia or the tibia of Ⅳ group was significantly less than that of the injected side tibia. Lots of FNPB were obviously sequestrated by other nonhematopoietic organs like the lungs by Ⅳ injection. (2) The recovery of hematopoietie and immunological function of IBM group was remarkably faster than Ⅳ group and its engraftment level and survival rate were improved without GVHD. By+90 d, the survival rate was 90％ and the level of H-2D~b+ cells in the injected side tibia BMNCs of IBM group was(29.53±6.64)％. (3) The engraftment level of HSCs and the hematopoietic reconstruction of the IBM-injected side tibia were much better than the noninjected side. [Conclusion] The murine model for allogeneic umbilical cord blood transplantation by intra-bone marrow injection was established successfully. It was confirmed that IBM-injection was better than Ⅳ-injection on facilitating the engraftment of HSCs, accelerating hemopoietie and immune recovery of recipients, and promoting the effect of UCBT. IBM-injection on multiple loci is probably more efficient to the homing of HSCs." @default.
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• W2386944738 date "2005-01-01" @default.
• W2386944738 modified "2023-09-22" @default.
• W2386944738 title "Establishment of a Murine Model for Allogeneic Umbilical Cord Blood Transplantation by Intra-bone Marrow Injection and Its Effects on the Engraftment of HSCs" @default.
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