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- W2386945105 abstract "Aquaporin(AQP) is a membrane protein that impacts the transmembrane transport of hydrone and regulates the balance of cellular exterior and interior environment.AQP-4 is the most highly expressed subtype of AQP in the brain,mostly distributed in the gliacyte,ependymal epithelium,contact face of lacouna(e.g.vascellum,subarachnoid cavity and ependymal epithelium),and bilateralis of Blood-Brain Barrier(BBB),and plays an important role in the process of hydrone passing through the BBB.In brain edema originated from different agents,such as cerebral infarction,brain hemorrhage,encephalon tumor and cerebral trauma,the expression level of AQP-4 changes,and AQP-4 closely correlates with the generation and development of brain injury and brain edema.The higher expression of AQP-4 around the hematoma after cerebral hemorrhage always accompanies with the destruction of the BBB permeability,the neurologic impairment,and the aggravation of hydropsia.Lower level of AQP-4 delays or prevents the cerebral edematization.Based on the relationship of AQP-4 and the brain edema generation and elimination,AQP-4and AQP-4 regulators can provide new paths to develop medicines for brain edema." @default.
- W2386945105 created "2016-06-24" @default.
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- W2386945105 date "2012-01-01" @default.
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- W2386945105 title "AQP-4 AND BRAIN EDEMA" @default.
- W2386945105 hasPublicationYear "2012" @default.
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