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- W2386948167 abstract "OBJECTIVE:To study the remission effect and mechanism of budesonide on airway inflammation in asthmatic rats.METHODS:Rats were randomly divided into normal control group,model group and budesonide low-dose,medium-dose and high-dose groups(0.25,1,2 mg/kg) with 10 rats in each group.The asthmatic model was established in those groups by the ovalbumin(OVA)provocation methods,except for normal control group.Budesonide group was given aerosol inhalation of budesonide solution for 10 min each time,twice a day for consecutive 7 days,30 min before aerosol inhalation of OVA since the 14th day.Blood and bronchoalveolar lavage fluid(BALF)were collected 24 h after the last inhaling budesonide.The levels of eosinophilic granulocyte(Eos),IL-4,IgE and thymus and activation regulated chemokine(TARC)in serum and BALF were measured.RESULTS:Compared with normal control group,the number of Eos,the contents of IL-4,IgE and TARC in serum and BALF were increased significantly in model group and budesonide low-dose group(P0.05);there was no statistical significance in above index of budesonide medium-dose and high-dose groups(P0.05).Compared with model group,the number of Eos,the contents of IL-4,IgE and TARC in serum and BALF of budesonide medium-dose and high-dose groups were decreased significantly(P 0.05);there was no statistical significance in above index of budesonide low-dose group(P0.05).CONCLUSIONS:Budesonide can relieve airway inflammation in asthmatic rats in dose-dependant manner,which may be associated with the decrease of TARC." @default.
- W2386948167 created "2016-06-24" @default.
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- W2386948167 date "2013-01-01" @default.
- W2386948167 modified "2023-09-25" @default.
- W2386948167 title "Remission Effects and Mechanism of Budesonide on Airway Inflammation in Asthmatic Rats" @default.
- W2386948167 hasPublicationYear "2013" @default.
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