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- W2386965563 abstract "Objective: To evaluate the efficacy and toxicity of thalidomide combination with cyclophosphamide and dexamethasone (TCD) in 12 patients with relapsed or refractory multiple myeloma. Method: Thalidomide 350 mg to 400 mg/d, cyclophosphamide 50 mg/d and dexamethasone 40 mg/d (were taken d1-4, 9-12, 17 - 20 in the first month; d1- 4, 9-12 in the second month; and then monthly for 1-4 day) in all patients. The rate of effects, time-action, survival and side effects were investigated. Result:The complete remission, partial remission and minimal response were 2, 3 and 1 cases respectively and the no change (NO was 6 cases. The rate of effects was 50%. The remission-time was 2-6 months. The survival time was 8 - 34months. All patients had neuropathy. Bradycardia, constipation, pulmonary thromboses, neutropenia and infection were 6, 8, 1, 2, and 2 cases respectively. Conclusion: TCD regimen is useful and safety in the treatment of relapsed and refractory multiple myeloma, it has a longer smooth-time and less side effects." @default.
- W2386965563 created "2016-06-24" @default.
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- W2386965563 date "2006-01-01" @default.
- W2386965563 modified "2023-09-24" @default.
- W2386965563 title "The efficacy of thalidomide with cyclophosphamide and dexamethasone in the treatment of 12 cases with relapsed and refractory multiple myeloma" @default.
- W2386965563 hasPublicationYear "2006" @default.
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