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- W2386979329 abstract "Objective To investigate dynamic changes of poly adenosine diphosphate-ribose polymerase-1(PARP-1)and apoptosis-inducing factor(AIF)in the mitochondria,cytoplasm,nucleus of cerebral cortex cell of neonatal rats with hypoxic-ischemic brain damage(HIBD),and explore the PARP-1 induced nuclear AIF translocating mechanism and the role of AIF playing in HIBD.Methods Seven-day-old Sprague-Dawley rats were randomly assigned into 2 groups:sham operation group and hypoxic-ischemic(HI)group,then they were further divided into 6 subgroups according to the time points 3 h,6 h,12 h,24 h,3 d,7 d.There were 8 rats in each subgroup.Subcellar fractionation were extracted from cerebral cortex tissue,and Western blot was used to detect the dynamic changes of AIF and PARP-1 in subcellar fractionation.Apoptosis cells of cortex were detected by terminal deoxynuleotidyl transferase meditated dUTP-biotin nick end labeling.Results 1.AIF expression of mitochondria in sham operation group was the same at different time points.In cytoplasm it had only very low expression.But no AIF expression were detected in nuclear.The amount of AIF in mitochondria in HI group began to increase at 3 h and reached peak at 6 h,then gradually declined,AIF expression had no significant difference between HI group and sham operation group at 7 d(P0.05).AIF translocation to the cytoplasm and nucleus began as early as 3 h after HI,and there were significantly increased at 24 h after HI and then gradually declined,and it still was higher than sham operation group until 7 d(P0.05).2.A few of PARP-1 was found in the nucleus,but in the cytoplasm and mitochondria no PARP-1 were detected.3.The number of apoptotic cells in the cerebral cortex of ipsilate-ral hemisphere began to increase at 3 h and peaked at 24 h and then decreased after HI.Conclusions Expression of AIF in the mitochon-dria,cytoplasm and nucleus of cerebral cortex cells increased after HI.Peak of AIF expression in cytoplasm and nucleus lagged behind mitochondria;the number of apoptotic cells increased after HI,which was consistent with AIF nuclear translocation;PARP-1 could not translocate to mitochondria and directly induce AIF nuclear translocation." @default.
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- W2386979329 date "2011-01-01" @default.
- W2386979329 modified "2023-09-28" @default.
- W2386979329 title "Expressions of Poly Adenosine Diphosphate-Ribose Polymerase-1 and Apoptosis-Inducing Factor in Subcellar Fractionation in Neonatal Rats with Hypoxic-Ischemic Brain Damage" @default.
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