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- W2386987888 abstract "Objective To investigate the roles of glutamate and glutamate carriers in the underlying mechanisms of Parkinson's disease(PD).Methods The platelet mitochondria of patients with PD were extracted,to load the mitochondria with glutamate and oxaloacetic acid respectively,then to trigger the transporting of the glutamate carrier by adding the ~(14)4C-glutamate and determine the activities of the carriers,and finally to observe the changes of the activity of the carriers in the presences of dopamine,L-dopa,trihexiphenidyl and amantadine.Results There was no significant change in the platelet counts in the PD patients,but the activity of glutamate carrier obviously decreased in them as compared with thc control group(P0.05).The amantadine could increase the activity(P0.05 vs non-drug treatment group).Other drugs used in our study showed no effects(P0.05 vs non-drug treatment group).Conclusion The glutamate and its carriers do play a role in the pathogenesis of Parkinson's disease,and the therapeutic efficacy of amantadine could be partly relevant to its effect on glutamate carrier." @default.
- W2386987888 created "2016-06-24" @default.
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- W2386987888 date "2007-01-01" @default.
- W2386987888 modified "2023-09-25" @default.
- W2386987888 title "Effect of amantadine on the activity of mitochondrial glutamate carrier in patients with Parkinson's disease" @default.
- W2386987888 hasPublicationYear "2007" @default.
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