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- W2386988411 abstract "The ibuprofen-loaded microparticles were prepared with poly(D,L-lactide) (PLA), poly(D,L-lactide-co-glycolide) (PLGA), tristearin and glyceryl behenate (Compritol) as carrier materials, respectively. The compatibility and the distribution between the carriers and ibuprofen were investigated by DSC, XRD and DPD (dissipative particle dynamics) simulation technique. The entrapment efficiency and release performance of the drug-loaded microparticles were also studied. The better compatibility between the drug and the carrier can cause the drug-loaded microparticles to have a higher entrapment efficiency of the drug, and the more uniform dispersion of the drug molecules in the carrier matrix can cause the drug-loaded microparticles to have a sustained release performance. The DPD simulation shows that the ibuprofen molecules are distributed in the inner area of the carrier matrix when PLA or PLGA is used as carrier, while they will be adsorbed on the surface or distributed in the outer area of the carrier matrix when tristearin or Compritol is used as carrier. It shows that the in vitro ibuprofen release of the polymeric PLA or PLGA microparticles is slower than that of tristearin or Compritol microparticles. Therefore the polymeric microparticles are more suitable to be used as the carrier for drug-loaded microparticles with long term sustained release preformance." @default.
- W2386988411 created "2016-06-24" @default.
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- W2386988411 date "2008-01-01" @default.
- W2386988411 modified "2023-09-29" @default.
- W2386988411 title "The Carrier Materials and the Release Performance of Drug-Loaded Mirco-Particles:Dissipative Particle Dynamics Simulation and Experiments" @default.
- W2386988411 hasPublicationYear "2008" @default.
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