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- W2386989237 abstract "Patch clamp technique was used to study the inhibitory effect of omethoate, an organophosphorous pesticide, on the membrane of embryonic Xenopus muscle cells in culture. By whole cell clamp and cell attached clamp, we found that both miniature end plate current (MEPC) and single channel current were directly inhibited by omethoate. Omethoate increased the amplitude and frequency of MEPC at a lower concentration (8.64 mol·L 1 ) and decreased them at a higher concentration (30.16 mol·L 1 ). The omethoate at a concentration of 659 mol·L 1 shortened the opening time and decreased the opening probability of the single channel. This result shows that omethoate is an AChR channel opening blocker." @default.
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- W2386989237 date "1997-01-01" @default.
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- W2386989237 title "Blocking effects of omethoate on acetylcholine receptor channels" @default.
- W2386989237 hasPublicationYear "1997" @default.
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