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- W2386999256 abstract "Objective: To investigate the expressions of matrix metalloproteinases(MMPs) in osteosarcomas and their relationship with local invasion and metastasis. Methods: Tumor biopsies from 40 cases of ⅡB osteosarcomas were chosen to study the expressions of MMP-7, MMP-9 and MMP-10 with immunohistochemistry, and their relationships with disease-free survival were analysed with Spearman, Kaplan-Meier methods and Cox regression model. Results: The expression rates of MMP-7, MMP-9 and MMP-10 were 62.5%(25/40), 67.5%(27/40) and 42.5%(17/40), respectively. Spearman test showed that patients with metastasis and recurrence had higher MMP-7, MMP-9 and MMP-10 expression rates than those with disease-free survival(P0.05). Single variable analysis showed that the patients with positive expressions of MMP-7, MMP-9 or MMP-10 had significantly lower disease-free survival rates than those with negative staining (P0.05). The analysis on patients who received adjuvant chemotherapy had the similar results. Multivariate analysis showed that only the expression of MMP-9 was an independent prognostic factor for disease-free survival. Conclusion: MMP-7, MMP-9 and MMP-10 are expressed in osteosarcoma cells and correlate with high invasive and metastatic tendency,but only MMP-9 correlates with prognosis significantly." @default.
- W2386999256 created "2016-06-24" @default.
- W2386999256 creator A5036970319 @default.
- W2386999256 date "2004-01-01" @default.
- W2386999256 modified "2023-09-23" @default.
- W2386999256 title "Relationship of MMP-7, MMP-9 and MMP-10 expressions with invasion and metastasis in osteosarcomas and its clinical significance" @default.
- W2386999256 hasPublicationYear "2004" @default.
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