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- W2387001489 abstract "Objective: : To investigate the effects of antisen se oligonucleotide directed to TNF-α on the water content of the brain following craniocerebral explosive injury. Methods: Eighteen dog s were randomly divided into artificial cerebral spinal fluid (ACSF) group, sens e and antisense group. With the model of explosive injury to craniocerebral we d eveloped, ACSF, the sense oligonucleotide to TNF-α and the antisense oligonucl eotide to TNF-α were administered respectively in 3 groups through preinjectio n into cerebellomedullar cisterna, and the water contents of the brain in the bi lateral hemispheres in the 3 groups were measured. Results: As c ompared to the ACSF groups and the sense groups, the water contents in the antis ense groups were significantly reduced ( P 0.05) 6 h post-trauma in all the bilateral hemispheres. Conclusion: Antisense oligonucleotide directe d to TNF-α can attenuate brain edema following the craniocerebral explosive in jury." @default.
- W2387001489 created "2016-06-24" @default.
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- W2387001489 date "2001-01-01" @default.
- W2387001489 modified "2023-09-25" @default.
- W2387001489 title "Effects of antisense oligonucleotides directed at TNF-α on brain water content following craniocerebral explosive injury" @default.
- W2387001489 hasPublicationYear "2001" @default.
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