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- W2387003886 abstract "Objective To investigate the effect of combined transplantation of human umbilical cord derived mesenchymal stem cells(hUC-MSCs)and hematopoietic stem cells on acute myloid leukemia.Methods The patient with acute myloid leukemia received marrow and peripheral blood stem cell transplantation(UD-PBSCT)with granulocyte clony-stimulating factor(G-CSF).hUC-MSCs were isolated,culture-expanded from human umbilical cord after enzyme digestion,and cotransplantation to patient with haplo-hematopoietic stem cells.The donor of haplo-hematopoietic stem cells was her elder-brother.Graft-versus-host disease(GVHD)was prevented with CsA,MTX,ATG,CD25 and mycophenolate mofetial.Results The number of MNCs and CD34+ cells was 7.92×108/kg and 4.1×106/kg,respectively in the donor.The number of neutrophils and platelets was over 0.5×109/L and 20×109/L on days 14 and 15,respectively.On day 24,the chimeras accounted for 100%.Grade 1 aGVHD was observed on about day 40,and no other severe complications occurred after treatment.Conclusion Transplantation of combined haplo-hematopoietic stem cells and hUC-MSCs is safe and simple,and can promote the function recovery of hematopoietic cells." @default.
- W2387003886 created "2016-06-24" @default.
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- W2387003886 date "2010-01-01" @default.
- W2387003886 modified "2023-09-26" @default.
- W2387003886 title "Transplantation of combined haplo-hematopoietic and human umbilical cord-derived mesenchymal stem cells for acute leukemia:A case report" @default.
- W2387003886 hasPublicationYear "2010" @default.
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