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- W2387005534 abstract "【Objective】To investigate the effect of FK506 on TNF-α,p~(38)MAPK protein expression at different ischemia-reperfusion points.【Methods】Ninety normal male Sprague-Dawley rats were randomly divided into 3 groups: sham-operated(sham) group,ischemia-reperfusion(IR)group,FK506+ischemia-reperfusion(FK506+IR)group.FK506+IR group was subjected to ischemia-reperfusion injury with intravenous administration of FK506(0.3 mg/kg)6 h before ischemia.IR group with the same injury was followed by saline administration in the same manner.Sham group was subjected to only anesthetization and laparotomy but not to ischemia.Pathomorphological changes of renal ischemia-reperfusion injury were observed by HE stain and two-step immunohistochemical methods were used to detect the changes of expression of TNF-α,p~(38)MAPK.【Results】TNF-αmainly expressed in renal proximal convoluted tubules,gradually upregulated with duration of ischemia-reperfusion and peaked at 12 h of reperfusion,but these effects were offset by administration of FK506(P0.05).p~(38)MAPK mainly located at distal convoluted tubules,peaked at 6 h of reperfusion and was decreased significantly by injection of FK506(P0.01).In IR group local necrosis and inflammatory cell infiltration were found by HE stain,while similar changes were scarcely visible in FK506+IR group.【Conclusion】Renal ischemia-reperfusion injury can be alleviated by FK506 treatment." @default.
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- W2387005534 date "2006-01-01" @default.
- W2387005534 modified "2023-09-25" @default.
- W2387005534 title "Effect of FK506 on TNF-α,p~(38)MAPK Protein Expression in Renal Ischemia-reperfusion Injury of Rats" @default.
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