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- W2387013558 abstract "Objective To investigate the effects on angiogenesis ability of circulating endothelial progenitor cells of acute lung injury. Methods Adult New Zealand white rabbits were divided into 5 groups: normal control group,ALI group,ALI + SDF- 1α treatment group,ALI + SDF- 1α treatment + CXCR4 blocker group,and acute lung injury +SDF- 1α treatment + CXCR7 blocker group. By density gradient centrifugation,mononuclear cells were obtained from peripheral blood and cultured for 7 days. The adherent cells were subsequently identified as the angiogenesis ability was assessed. Results The number of blood vessels was significantly less in the ALI group than control group( P 0. 05).Significant increase in blood vessels in ALI + SDF- 1α treatment group was observed compared to ALI group( P 0. 05). There was no significant difference in blood vessel number among ALI group,ALI + SDF- 1α treatment + CXCR4 blocker group and ALI + SDF- 1α + CXCR7 blocker treatment group( P 0. 05). Conclusion The angiogenesis ability of EPCs is impaired in ALI rabbits,which can be reversed with SDF- 1α inhalation therapy. The effect of SDF-1α is blocked by CXCR4 and CXCR7 receptor blockers." @default.
- W2387013558 created "2016-06-24" @default.
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- W2387013558 date "2013-01-01" @default.
- W2387013558 modified "2023-09-23" @default.
- W2387013558 title "The effects of SDF-1α/CXCR4 and SDF-1α/CXCR7 on the angiogenesis ability of circulating endothelial progenitor cells of acute lung injury in vitro" @default.
- W2387013558 hasPublicationYear "2013" @default.
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