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- W2387016087 abstract "Objective: To investigate the effects of cage-running exercises on apoptosis of neuronal cells surrounding the hematoma in ICH rats. Method: A total of 120 male SD rats were randomly divided into three groups, trial group (ICH with EX n=40), control group( ICH with no EX n=40) and sham operated group (no ICH, no EX n=40). The rats brains were harvested at the 24th h,7th d,14th d,21st d,28th d after ICH. Terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate-bioti in situ nick end-labeling(TUNEL) was used to detect deoxyribonucleic acid(DNA) fragmentation. Flow cytometry assay(FCA) was quantified for DNA. Result: ①TUNEL-positive cells appeared in the periphery of hematoma and hippocampus. The number of TUNEL-positive cells was nearly zero in the sham-operated group, and this number increased markedly in control group from the 14th d to 28th d after ICH, but it reduced in trial group at the same time. Even though, the number of TUNEL-positive cells in two groups once decreased from the 7th—14th d, but the number of TUNEL-positive cells in trial group was less than that in control group. There was a significant difference between two groups(P0.05). ②The apoptotic regularity of flow cytometry assay was similar to that of TUNEL-positive cell. But the apoptotic rate of neuronal cells in Annexin Ⅴ-P was more higher than that in PI. Conclusion: Exercises training (cage-running) can inhibit the number of apoptotic cells." @default.
- W2387016087 created "2016-06-24" @default.
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- W2387016087 date "2008-01-01" @default.
- W2387016087 modified "2023-09-23" @default.
- W2387016087 title "The physical exercises effect on apoptosis of neuronal cells surrounding intracerebral hemorrhage in rats" @default.
- W2387016087 hasPublicationYear "2008" @default.
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