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- W2387016406 abstract "Objective To explore the gene expression of nuclear receptor corepressor(NCoR) in androgen independent prostate cancer(AIPC) and its clinical significance.Methods The expression of NCoR and androgen receptor(AR) was detected by two-stage immunohistochemical method in 15 cases with AIPC,20 cases with androgen dependent prostate cancer(ADPC) and 20 cases with benign prostatic hyperplasia(BPH) respectively.Results The rate of NCoR expression in AIPC,ADPC and BPH was 20%,80% and 95% respectively and the difference of NCoR expression between AIPC and ADPC,BPH was significant(P0.01).The rate of NCoR expression in low-differentiated, middle-differentiated and high-differentiated prostatic carcinoma(Pca) was 24%,73% and 100% respectively and the difference of NCoR expression among three groups was significant(P0.05).Based on different stages of tumour,the rate of NCoR expression was 22%(D),66%(C),100%(B) and 100%(A),and the difference of NCoR expression between D and A,B,C,C and A,B was significant(P0.01).Conclusion Androgen independence of Pca may be correlated with the decreasing of NCoR protein." @default.
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- W2387016406 date "2006-01-01" @default.
- W2387016406 modified "2023-09-23" @default.
- W2387016406 title "Gene expression of nuclear receptor corepressor in androgen independent prostate cancer and its clinical significance" @default.
- W2387016406 hasPublicationYear "2006" @default.
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