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- W2387017908 abstract "Objective To explore the relationship between iodide ion and vascular endothelial growth factor(VEGF) as well as its receptor in vascular endothelial cells(VEC) proliferation.Methods(1) The detection of the proliferation rate of vascular endothelial cell after it reacted to iodide ion and VEGF inhibitor was performed by using CCK-8 kit.(2) The detection of the influence of iodide ion on the phosphorylation of VEGFR-2 was carried out by using Western Blot technique.Results(1) The VEGF inhibitor could not suppress the proliferation of vascular endothelial cell in concentration of 300 μg/L of iodide ion(P 0.05).(2) A certain concentration of iodide ion could stimulate the phosphorylation of VEGF-2(Tyr1214)(P 0.05).(3) Iodide ion could not affect the phosphorylation of VEGF-2(Tyr1175 and Tyr951 loci).Conclusion(1) Iodide ion can stimulate the proliferation of VEC,and it does not depended on the stimulation of membrane receptor from VEGF.Therefore,iodide ion can be regarded as an independent element in stimulating the proliferation of vascular endothelial cell.(2) The iodide ion can mediate the migration of vascular endothelial cell through stimulating the phosphorylation of VEGF-2(Tyr1214).(3) The iodide ion has no effect on the phosphorylation of VEGFR-2(Tyr1175).The stimulation of iodide ion to the proliferation of VEC is accomplished not by way of acting on the membrane receptor." @default.
- W2387017908 created "2016-06-24" @default.
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- W2387017908 date "2013-01-01" @default.
- W2387017908 modified "2023-09-25" @default.
- W2387017908 title "The relationship between iodide ion and vascular endothelial growth factor together with its receptor in vascular endothelial cell proliferation" @default.
- W2387017908 hasPublicationYear "2013" @default.
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