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- W2387029283 abstract "Objective To investigate the effects of mitomycin C (MMC) on the cell replication activity in different applied methods following experimental filtration surgery.Methods During trabeculectomy in rabbits eyes ,MMC (0.4g·L -1 ) was applied on episcleral for 5 minutes before preparations of a half-thickness scleral flap in one group; MMC was applied on episcleral for 3 minutes combined with in scleral bed for 2 minutes in another group. The control group underwent the same treatment but with balanced salt solution. At 1?4?7?14 and 28 days after surgery, we observed histological changes and expression of proliferation cell nuclear antigen in the filtering area. Results In the MMC-treated eyes, the immunoreactive cells began to increase 4 days after surgery. But the number of immunoreactive cells in the treated eyes was much lower than that in controls. There was no significant difference between the two MMC-treated groups.Conclusion MMC suppresses the proliferation of fibroblasts in the filtering site, and no differences are found between the two MMC-treated groups ." @default.
- W2387029283 created "2016-06-24" @default.
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- W2387029283 date "2002-01-01" @default.
- W2387029283 modified "2023-09-22" @default.
- W2387029283 title "Experimental study of anti-proliferative effects of mitomycin C" @default.
- W2387029283 hasPublicationYear "2002" @default.
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