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- W2387043097 abstract "Objective To observe the effect of thalidomide(Tha) combined with arsenic trioxide(AsT) on the growth of SMMC7721 xenografts and to investigate the possible mechanism.Methods Thirty-five male BALB / c nude mice subcutaneously injected with 0.2 mL cell suspension(5 × 107/ mL) of human hepatoma cell line SMMC7721,were randomly divided into seven groups,5 in each: the high dose Tha group(HTha) intraperitoneal injected Tha 25 mg / kg,low dose Tha group(Ltha) intraperitoneal injected Tha 2.5 mg / kg,the AsT group(AsT) intraperitoneal injected AsT 2.5 mg / kg,the HTha + AsT group(HTha + AsT) intraperitoneal injected Tha 25 mg / kg + AsT 2.5 mg / kg,the LTha + AsT group(LTha + AsT) intraperitoneal injected Tha 2.5 mg / kg + AsT 2.5 mg / kg,negative control group intraperitoneal injected CTX 20 mg / kg and the positive control group intraperitoneal injected normal saline 20 mL / kg.All groups were treated for 4 weeks.The volume of the xenografts was monitored,the action and reactions of nude mice were also observed.A month later,the mice were sacrificed for partial tumor tissues;the expression of VEGF mRNA was measured by RT-PCR,the expression of the Bax and caspase-3 was also detected by immunohistochemisty.Results The tumor formation rate was 100% by HE staining.The tumor volume in each group: HTha + AsT LTha + AsT HTha LTha AsT positive control negative control,the difference was statistically significant(all P 0.05);expression of VEGF mRNA in xenografts: HTha + AST LTha + AST HTha Ltha AsT positive control negative control,the difference was statistically significant(all P 0.05);the expression of Bax and caspase-3: HTha + AsT LTha + AST AsT HTha LTha positive control negative control,the difference was statistically significant(all P 0.05).Conclusion Tha combined with AsT can significantly inhibit the growth of SMMC7721xenografts,better than the single therapy;their mechanisms are associated with the down-regulation of VEGF mRNA expression to inhibit tumor angiogenesis,the up-regulation of the expression of Bax and Caspase-3 to promote cell tumor apoptosis,respectively." @default.
- W2387043097 created "2016-06-24" @default.
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- W2387043097 date "2013-01-01" @default.
- W2387043097 modified "2023-09-27" @default.
- W2387043097 title "Effect of Tha combined with AsT on the growth of SMMC7721 Xenografts and its mechanism" @default.
- W2387043097 hasPublicationYear "2013" @default.
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