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- W2387049323 abstract "Objective To investigate the association between anti-glomerular basement membrane antibodies against different target antigens and the clinical phenotypes of patients with anti-GBM disease.Methods The target antigens of 97 sera from patients with anti-GBM disease diagnosed in our hospitals in the period from 1998 to 2008 were investigated by enzyme-linked immunosorbent assay (ELISA) using recombinant human1,2,3,4 and 5 (IV) NC1 as the solid phase antigens.Sixty-nine sera were further examined by indirect immunofluorescence using normal human renal tissue as the substrates.Sections were pre-treated with 6M urea to unmask the cryptic epitopes,and untreated sections were used to detect natural exposed epitopes.Their associations with clinical and pathological data were analyzed.Results 3 (IV) NC1 could be recognized by sera from all patients,1 (IV) NCI by 56.7% sera,2 (IV) NC1 by 43.3% sera,4 (IV) NC1 by 53.6% sera,and 5 (IV) NC1 by 85.6% sera.The level of anti3 (IV) NC1 antibodies was the independent risk factor to the level of serum creatinine at presentation (r=0.308,P =0.003) and to the percentage of crescents in glomeruli (r=0.492,P 0.001).Patients with anti-5(IV)NC1 antibodies had a higher recognizing rate to natural exposed epitopes (67.3% vs 30.0%,P =0.026).The level of anti-5(IV) NC1 antibodies was positively correlated with the percentage of cellular crescents (P =0.013).Patients with positive antineutrophil cytoplasmic antibodies (ANCA) had a lower recognizing rate to 1 (IV) NC1 (7.3% vs 26.2%,P=0.011) and 4 (IV) NC1 (7.7% vs 24.4%,P=0.023).Conclusion The major target antigen of anti-GBM antibodies is 3(IV)NC,and the level of these antibodies is the independent risk factor to renal damage.Anti-5(IV)NC1 antibodies may recognize natural exposed epitopes on GBM,and these antibodies may play important roles in the pathogenesis of the disease.Anti-GBM antibodies from patients with positive ANCA have a narrow spectrum of target antigens." @default.
- W2387049323 created "2016-06-24" @default.
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- W2387049323 date "2010-01-01" @default.
- W2387049323 modified "2023-09-23" @default.
- W2387049323 title "Anti-glomerular basement membrane autoantibodies against different target antigens are related to patients' clinical phenotype" @default.
- W2387049323 hasPublicationYear "2010" @default.
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