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- W2387060209 abstract "Objective:To investigate the effects of donor-specific transfusion(DST)and different doses of FK506 on the survival of homologous cardiac transplantation in mice.Methods:Male BALB/C(H-2d)mouse hearts were transplanted to male C57BL/6 (H-2b)mice using Chen's model.Mice were randomly divided into four groups:the control group,the DST group,the DST/FK506(2 mg/(kg·d))group and the DST/FK506(0.3 mg/(kg·d))group.Their duration of survival,pathological changes in cardiac muscle,and serum IL-2,IL-4,IL-10 and INF-γlevels were compared.Results:①DST used at the day before operation and FK506 used sequently from the beginning to the end,the longer cardiac allograft survival was observed in the DST/FK506(2 mg/(kg·d))group and the DST/FK506(0.3 mg/(kg·d))group than those in the control group(P0.01).Among DST/FK506 groups,the low dose of FK506 as aid to DST was the most effective(group 4 vs group 3,P0.05).②Pathological changes:Seven days after transplantation,severe rejec- tions were found in mice in group 1 and group 2 with histological grading above 3.Mild rejections were found in mice treated with FK506 and DST in group 3 and group 4 with histological grading no more than 2.③Serum cytokine levels:IL-2 levels in group 3 and group 4 were higher compared with that in group 1 and group 2.IL-4 levels in group 3 and group 4 were lower compared with that in group 1 and group 2.IL-10 levels in group 3 and group 4 were lower compared with that in group 1 and group 2.INF-γlevels in group 3 and group 4 were higher compared with that in group 1 and group 2.Conclusion:DST and low dose FK506 can effectively sup- press acute rejection after cardiac allo-transplantation in mice,and prolong the murine cardiac allograft survival." @default.
- W2387060209 created "2016-06-24" @default.
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- W2387060209 date "2008-01-01" @default.
- W2387060209 modified "2023-09-23" @default.
- W2387060209 title "Effects of Donor-Specific Transfusion and FK506 on Cardiac Allo-transplantation in Mice during Acute Rejection" @default.
- W2387060209 hasPublicationYear "2008" @default.
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