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- W2387072145 abstract "Objective To study the DNA methylation and expression of ALX4 gene in normal tissue,tumor tissue form lung cancer and cancer cell lines.Methods The MSP(methylation specific PCR) was used to detect the DNA methylation of ALX4 gene.The RT-PCR was used to analyze the expression of ALX4 gene in 5-aza-dC-treated tumor cells.Results The hypermethylation of ALX4 was detected in lung cancer tissues(55%,11/20),but not in normal tissues(0%,0/10).In 8 cancer cell lines,ALX4 showed hypermethylation and its expression decreased.The expression of ALX4 gene was missed in cancer cell lines with methylation.After treatment with demethylation drug,the expression of ALX4 gene was increased in these cell lines.Conclusion ALX4 showes hypermethylation in lung cancer and cancer cell lines and the methylation inhibits its gene expression,suggesting that ALX4 gene may play an important role in lung cancer." @default.
- W2387072145 created "2016-06-24" @default.
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- W2387072145 date "2013-01-01" @default.
- W2387072145 modified "2023-09-25" @default.
- W2387072145 title "DNA Methylation and Expression of ALX4 Gene in Cancer" @default.
- W2387072145 hasPublicationYear "2013" @default.
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