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- W2387079424 abstract "Objective: To compare plasma levels of platelet activating factor(PAF) before and after drug eluting stent(DES) implantation in patients with stable coronary heart disease(CHD),and explore the association between baseline PAF level and cardiovascular events.Methods: A total of 88 cases with stable CHD were enrolled from August 2007 to December 2008.Data of clinical characteristics,coronary angiography(CAG) and percutaneous coronary intervention(PCI) were collected in these patients.Enzyme linked immunosorbent assay was used to measure plasma level of PAF(aortic root) in all patients before PCI.According to stratification of baseline PAF level,patients were followed up to one year after PCI for main cardiovascular events.After DES implantation for a mean eight months,29 patients with stable CHD were measured for CAG and PAF again.Results: After DES implantation eight months,PAF concentration was significantly lower than baseline level [(236.25±17.78)pg/ml vs.(349.92±38.44)pg/ml,P=0.0109].After follow up to mean 12.5 months,combine end-point of cardiovascular events(death,nonfatal ACS,repeated PCI and rehospitalization)significantly increased in high PAF level(PAF≥260pg/ml)group compared with that in low PAF level(PAF260pg/ml)group(RR=1.714,95%CI:1.051~2.796,P=0.031).Conclusion: PAF level in patients with stable CHD is related with short-term main cardiovascular events.After DES implantation eight months,PAF level significantly decreases which might be attributed to inhibition of inflammatory reaction and activation of platelet." @default.
- W2387079424 created "2016-06-24" @default.
- W2387079424 creator A5061358533 @default.
- W2387079424 date "2011-01-01" @default.
- W2387079424 modified "2023-09-26" @default.
- W2387079424 title "Change of level of platelet activating factor after drug eluting stent implantation in patients with stable coronary heart disease and its significance" @default.
- W2387079424 hasPublicationYear "2011" @default.
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