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- W2387093909 abstract "Objective To discuss the correlation between Skp2 and the prognosis and other clinicopathological features of nasal type NK/T-cell lymphoma. Methods We collected the clinicopathological data of 95cases of nasal type NK/T-cell lymphoma,detected the expression of EBV encoded RNA(EBER),Skp2 and Ki-67 of paraffin-embedded tissue of tumors using immunohistochemical method.The cases with the Skp2-positive rate of tumor cells above 50% were classified into high expression group,those with below 50% were classified into low expression group. We analyzed the correlation between the expression of Skp2and Ki-67,and the prognosis or EBER status. Results In the high expression group,the mean overall survival was 20.54months(95%CI: 18.49-22.59),the 1-year overall survival rate was 76%.In the low expression group,the mean overall survival was 17.54months(95%CI:20.31-22.24),the 1-year overall survival rate was 71%.In the negative expression group,the mean overall survival was 21.71 months(95%CI:11.15-16.18),the 1-year overall survival rate was 91%.There was statistical difference between Skp2high expression group and Skp2negative expression group(P0.01). Conclusions The high expression of Skp2maybe an independent unfavorable prognosis factor of nasal type NK/T-cell lymphoma." @default.
- W2387093909 created "2016-06-24" @default.
- W2387093909 creator A5035064408 @default.
- W2387093909 date "2014-01-01" @default.
- W2387093909 modified "2023-09-28" @default.
- W2387093909 title "The expression and clinical significance of Skp2 in nasal type NK/T-cell lymphoma" @default.
- W2387093909 hasPublicationYear "2014" @default.
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