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- W2387099653 abstract "【Objective】 This study was aimed to investigate the titer consistency in parallel between tissue-based IIFA and cell-based IIFA in Chinese patients with neuromyelitis optica(NMO) spectrum disorders.【Methods】 Every sample was tested by the tissue-based IIFA and cell-based IIFA separately.Positive serum samples were titrated in doubling dilutions,to ascertain the maximum dilution that yielded positive results separately.We assessed the seroprevalence and the titer consistency of anti-aquaporin-4 antibodies of serum samples from patients with neuromyelitis optica(NMO,19),recurrent optic neuritis(RON,17),longitudinally extensive transverse myelitis(LETM,13),multiple sclerosis(MS,31),health control(HC,30).Moreover,we analyzed the relation of anti-aquaporin-4 antibody titers and spinal cord lesions on MRI.【Results】 We noticed lack of concordance in titer detection in most samples between the two techniques.We found 63.2%(12/19) of NMO patients were seropositive for AQP4 antibodies by tissue-based IIFA versus 89.5%(17/19) by cell-based IIFA.47.1%(8/17) of RON patients were seropositive for AQP4 antibodies by tissue-based IIFA versus 70.6%(12/17) by cell-based IIFA.46.2%(6/13)of LETM patients were seropositive for AQP4 antibodies by tissue-based IIFA versus 69.2%(9/13) by cell-based IIFA.6.5%(2/31) of MS patients were seropositive for AQP4 antibodies by tissue-based IIFA versus 9.7%(3/31) by cell-based IIFA.The lengths of spinal cord lesions on MRI were not correlated with the titers of anti-AQP4 antibody in both assays.The two assays have no linear dependence in measuring this antibody titer.【Conclusion】 The current discrepancy between the two assays implies the necessity to study the potential impact on titers in both assays." @default.
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- W2387099653 date "2012-05-20" @default.
- W2387099653 modified "2023-09-27" @default.
- W2387099653 title "Comparative Analysis of Methods for Titrating Anti-aquaporin-4 Antibodies in Neuromyelitis Optica Spectrum" @default.
- W2387099653 hasPublicationYear "2012" @default.
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