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- W2387100609 abstract "Background and purpose:COX-2 plays an important role in the progress of glioma.Recently some studies show COX-2 inhibitors enhance the response of glioma to irradiation.The aim of this paper is to observe the expression of COX-2 in the human glioma cell and the effects of acetaminophen(ACE),a non-selective cyclooxygenase(COX)-2 inhibitor,on the SHG-44 cells in terms of the expression of COX-2 mRNA、clone efficiency and cell cycle.The mechanism of the radiosensitivity enhancement by the affection of ACE was also investigated.Methods:The human glioma cell SHG-44 was used as cell model.COX-2 mRNA and protein expression of SHG-44 were detected by RT-PCR and immunocytochemisty staining.Clongenic assay was used for radiation survival estimate.The cell cycle distribution was analyzed by flow cytometry.Results:COX-2 protein expression in cytoplasm and cell membrane of SHG-44 cells were demonstrated by the immunocytochemisty staining experiment.Lower expression of COX-2 mRNA in the SHG-44 cells was observed when cells were incubated with 1mmol/L acetaminophen.Acetaminophen could enhance tumor cell to irradiation,SER was 1.23(D0)or 1.43(Dq)by clonogenic assay.The G2/M arrest in R and R+A groups were significant as compared to group C after 12 hr treatment(P0.01),but the percentage of G2/M phase cells in R group decreased rapidly after 24 hr treatment and was the same as C group(P0.05),while the percentage of G2/M phase cells in R+A group still maintained a high leval(P0.01).Conclusions:There was expression of COX-2 in human glioma cell SHG-44.Acetaminophen significantly enhances radiosensitivity of SHG-44 glioma cells,probably via COX-2 inhibition,G2/M arrest or other mechanisms." @default.
- W2387100609 created "2016-06-24" @default.
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- W2387100609 date "2007-01-01" @default.
- W2387100609 modified "2023-09-24" @default.
- W2387100609 title "The impact of COX-2 expression on the radiosensitivity and cell cycle distribution in human glioma cell" @default.
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