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• W2387132316 abstract "【Objective】 To investigate whether the influence of two forms(long-acting / short-acting) of gonadotrophin-releasing hormone agonist(GnRH-a) on anti-Mullerian hormone(AMH) is the same. 【Methods】 The study included 869 cycles that underwent in vitro fertilization(IVF) / intracytoplasmic sperm injection(ICSI) from February 2012 to September 2012. Patients who met the inclusion criteria were randomly divided into two groups: long-acting group(using long-acting GnRH-a, Diphereline誖) which including 128 women with 128 cycles, and short-acting group(useing short-acting GnRH-a, Diphereline 誖) which including 116women with 116 cycles. Serum AMH levels were measured at baseline and Day 14 following GnRH-a. 【Results】 ① After downregulation in long-acting group, baseline serum AMH slightly reduced, P 0.05; In short-acting group, serum AMH fell from(2.92± 2.12) μg / L to(2.29 ± 1.54) μg / L(P 0.05). ② After GnRH-a treatment higher basal AMH level fell down, and lower basal AMH level grew up in both groups. Using rising or falling AMH level as the standard to the ROC curve, we found the cutoff point of serum AMH:2.15 μg / L in long-acting group, and 2.16 μg / L in short-acting group. ③In long-acting group, based on the cutoff points, basal AMH level of 52 women was less than 2.15 μg / L, and their basal serum AMH was(1.39 ± 0.54) μg / L, after downregulation AMH was(2.73 ± 1.83) μg / L(P 0.01); 76 women with basal serum AMH ≥2.15 μg / L, their basal serum AMH was(4.40 ± 1.95) μg / L, after down-regulation was(3.27 ± 1.78) μg / L(P 0.01). In short-acting group, 51 women with basal serum AMH 2.16 μg / L, AMH before down-regulation was(1.21 ± 0.50) μg / L, after down-regulation was(1.96 ± 1.57) μg / L(P 0.01); 65 women with basal serum AMH ≥2.16 μg / L, their basal serum AMH was(4.26 ± 1.93) μg / L, after down-regulation was(2.55 ± 1.48) μg / L(P 0.01). ④In long-acting group,for those whose AMH level 2.15 μ g / L, there was no significant difference of basal serum AMH between AMH increased group(1.39 ± 0.55) μg / L and decreased group(1.41 ± 0.38) μg / L, but the number of retrieved oocytes was less in falling group(13.40 ± 5.08 vs 7.40 ± 2.51, P 0.05). For those whose AMH level ≥ 2.15 μg / L,AMH increased group had lower basal AMH level( 3.39±0.89) μg / L than decreased group(4.65 ± 2.06) μg / L, but had more retrieved oocytes(17.73 ± 6.13 vs 13.79 ± 4.60, P 0.05). In short-acting group, we had the same results. 【Conclusion】 Whether using long-acting or short-acting GnRH-a, AMH dynamics after down regulation was the same: for those with basal serum AMH below the cutoff point, AMH had upward trend; for those with basal serum AMH higher than the cutoff point, AMH showed downward trend. Consistent with this variation trend, the expected number of oocytes retrieved would be better." @default.
• W2387132316 created "2016-06-24" @default.
• W2387132316 creator A5053735608 @default.
• W2387132316 date "2013-01-01" @default.
• W2387132316 modified "2023-09-25" @default.
• W2387132316 title "Influence of Gonadotropin-releasing Hormone Agonist on Serum Anti-Mullerian Hormone Level" @default.
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