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- W2387134003 abstract "Objective This study investigated whether Danhong Injection could protect perfused hearts of rats against ischemia/reperfusion injury(IR) when it was administered before the adverse ischemic event.Methods Studies were conducted in buffer-perfused isolated rat hearts.This experiment consisted of baseline perfusion for 20 min,warm global ischemia for 40 min and 2 hours of reperfusion.Preconditioning of hearts in L-prec and H-prec group was induced by 15 min of low(5 mg/L) or high(15 mg/L) concentration of Danhong Injection followed by 15 min of wash out.Untreated hearts served as ischemic control(ISCH) group.Left ventricular mechanical function(LVDEP,LVDP,±dp/dtmax),cardiac enzyme activity(CK,LDH),and infarct size(IS) were measured as variables of ventricular function and cellular injury,respectively.Results Danhong Injection preconditioning attenuated the release of CK and LDH and reduced the IS of the heart during reperfusion,compared with ISCH group(P0.05).There was no difference between L-prec and H-prec group with respect to myocardial enzyme activity and infarct size.Additionally,high concentration of Danhong Injection improved mechanical function comparing with ISCH group and L-prec group(P0.05).Conclusion Danhong Injection administered before the ischemia provides protective effects against reperfusion injury in isolated rat hearts.high concentration of Danhong Injection improved mechanical function." @default.
- W2387134003 created "2016-06-24" @default.
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- W2387134003 date "2012-01-01" @default.
- W2387134003 modified "2023-09-27" @default.
- W2387134003 title "Danhong Injection protects against myocardial reperfusion injury in isolated rat heart" @default.
- W2387134003 hasPublicationYear "2012" @default.
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