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- W2387159898 abstract "objectice:The large lesions of atherosclerosis characterized by the accumulation of foam cells.The interaction between macrophages with Lp(a)was studied to present how liporotein(a)plays roles in foam cell forming in the arterial wall.Methods:LP(a)binding assay with the mouse peritoneal macrophage were carried out by biotin avidin enzyme linked sorbent assay.The free and total cholesterol contents of the cells were determined after incubations with native Lp(a)or oxidizedLp(a)respectively by the enzymatic method.Results:Lp(a)was bound with affinity,saturation to macrophage surface.The value of Lp(a)binding with macrophages increased markedly after oxidative modification.The content of cholesterol in macrophages increased after incubating with LP(a)together whatever in native or oxidized Lp(a).oxidized Lp(a),however,induced higher rates of cholesterol accumulation,the values of content in cholesterol and its ester within macrophages increased 2.5-fold and6.1-fold than that in native Lp(a)respectively.Conclusions:Lp(a)can be bound to macrophages surface by special receptor,resulting enhanced uptake and degradation of Lp(a)by macrophages especially to the oxidized Lp(a)." @default.
- W2387159898 created "2016-06-24" @default.
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- W2387159898 date "2002-01-01" @default.
- W2387159898 modified "2023-09-25" @default.
- W2387159898 title "Relationship between Lipoprotein(a)and the CholestrolAccumulation in Macrophages" @default.
- W2387159898 hasPublicationYear "2002" @default.
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