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- W2387161217 abstract "Objective:To investigate the relationship between the Insulin-like growth factor-Ⅰ and atherosclerotic plaques and to explore its possible mechanism in patients with acute coronary syndrome (ACS). Method:We measured circulating levels of free IGF-Ⅰ and total IGF-Ⅰ in 77 patients with ACS(40 patients with acute myocardial infarction, 37 with unstable angina), 38 with stable angina (SAP) and 33 controls without atherosclerosis by ELISA. Result:Serum free IGF-Ⅰ was significantly higher in ACS than SAP (P 0.05); serum total IGF-Ⅰ was significantly lower in ACS and SAP than in controls(P 0.05), but have no significant difference among the coronary heart disease (CHD) subgroups (P 0.05). Free IGF-Ⅰ levels were not associated with the extent of diseased coronary artery and Gensini score, but total IGF-Ⅰ was significantly and inversely associated with Gensini score(P 0.01). Conclution:The lowered total IGF-Ⅰ levels have no relation to atherosclerotic plaque instability, which is not looked as the criteria marker of ACS. But the higher free IGF-Ⅰ levels take part in the development of atherosclerosis plaque which can indicate the instable plaque." @default.
- W2387161217 created "2016-06-24" @default.
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- W2387161217 date "2005-01-01" @default.
- W2387161217 modified "2023-09-27" @default.
- W2387161217 title "Plasma insulin-like growth factor-I level in acute coronary syndrome" @default.
- W2387161217 hasPublicationYear "2005" @default.
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