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- W2387163412 abstract "Objective To explore the effect of Bushen huoxue decoction(KTBQF) on vascular endothelial growth factor mRNA expressionon polycystic ovary model of rats.Methods 60 SD female rats aged 24 days were divided into high and low dosage of KTBQH groups,model group,western medicine group and normal control group,12 rats in each group.The models were prepared with Bogovich method,and the effects of KTBQH on VEGFmRNA levels were investigated with Chloramiphene as control and hybridization in situ.Results The expressions of VEGFmRNA in granular,thecal,interstitial and vascular cells of the model were increased remarkably.After the treated by KTBQF in both high and low dosage,the expression in ovary was decreased remarkably(P0.05 and P0.01),which showed that both KTBQF in high and low dosages and western medicine were effective to inhibit the expression of VEGFmRNA.The effect in high dose group of KTBQF was more effective than that in western medicine group(P0.01),and in low dose was not different(P0.05).Conclusion VEGFmRNA maybe participate in the pathogenesis of polycystic ovary syndrome.KTBQHF can decrease high expression of VEGFmRNA and action of VEGFmRNA in ovary,which shows that the decoction can invigorate the kidney and activate blood in ovary to improve the growth of follicle thus achieving the purpose of promoting the ovulation." @default.
- W2387163412 created "2016-06-24" @default.
- W2387163412 creator A5028288515 @default.
- W2387163412 date "2008-01-01" @default.
- W2387163412 modified "2023-09-23" @default.
- W2387163412 title "Effect of Bushen Huoxue decoction on vascular endothelial growth factor of polycystic ovary in rats" @default.
- W2387163412 hasPublicationYear "2008" @default.
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