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- W2387163924 abstract "Objective To observe the protein change and find potential biomarkers of myocardial ischemia in a rat model using surface-enhanced laser desorption /ionization time of flight mass spectrometry(SELDI-TOF MS).Such research may be useful for the diagnosis of acute cardiac ischemia and sudden cardiac death.Methods Sprague-Dawley rats were divided as three groups:operation group,sham operation group,non-operation group.The myocardiums were collected 5min~6h after the coronary artery ligation.Protein extracts were processed by CM10 ProteinChip and analyzed by SELDI-TOF MS.Results Three novel ischemia related peaks with m /z 6304Da,8337Da and 8375Da were only found in operation groups with the 100% positive rate and 100% specificity.Three ischemia related peak height increasing peaks were found:two of them,peak 6658Da and 6876Da increased in ≥15min groups,while peak 8577Da increased in ≥5 min groups.Conclusion Three novel myocardial ischemia related peaks 6304Da、8337Da、8375Da are specific for the myocardium ischemia.They appeared as early as 5 min after the onset of LAD liagation and may serve as the bismarkers of acute myocardial ischemia or ancillary ischemia sign for SCD." @default.
- W2387163924 created "2016-06-24" @default.
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- W2387163924 date "2008-01-01" @default.
- W2387163924 modified "2023-09-24" @default.
- W2387163924 title "Proteomic study of early expressed protein of myocardial ischemia" @default.
- W2387163924 hasPublicationYear "2008" @default.
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