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- W2387172169 abstract "Objective:To analyze gene expression profiling of left ventricular myocardium in patients with chronic congestive heart failure(CHF)caused by rheumatic heart disease(RHD)with the normal controls in order to identify CHF associated target genes.Methods:The gene expression profiles of left ventricular myocardium from patients with CHF by RHD and normal controls were obtained from six human whole-genomic oligonucleotide microarrays(Affymetrix HG U133 Plus 2.0 GeneChip).GeneSpring software was used to identify the differentially expressed genes in both groups,and bioinformatic analysis was applied to analyze the target genes associated with CHF.Real-time PCR was carried out to validate the expression of three target genes.Results:We identified 102 target genes associated with CHF which were classified into 7 gene clusters.Microarray results were further confirmed by real time PCR for three genes.ATF3 was markedly down-regulated,IGFBP2 and NPPB were notably up-regulated in the left ventricular myocardium samples from CHF patients.Conclusion:A lot of differentially expressed genes,obtained by using the whole-genomic expression profiling technology,might be a contributory factor for the initiation and progression of CHF and it helpful for the understanding of underlying pathophysiological implications.Further investigation on these genes would provide a strategy to identify genetic markers and molecular events associated with CHF caused by RHD." @default.
- W2387172169 created "2016-06-24" @default.
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- W2387172169 date "2009-01-01" @default.
- W2387172169 modified "2023-09-26" @default.
- W2387172169 title "Preliminary Study of Microarray Gene Expression Profiles in Chronic Congestive Heart Failure due to Rheumatic Heart Disease" @default.
- W2387172169 hasPublicationYear "2009" @default.
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