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- W2387189601 abstract "Objective To investigate the effect of Tong XinLuo and the mechanism of MAPK (mitogen activated protein kinases, ERK 1 and ERK 2) on the proliferation of neointimal after PTA (percutaneous translurminal angioplasty) model in atherosclerotic rabbit. Methods Set up atherosclerotic and PTA model in 60 rabbits, randomly divided into 3 groups,control group 20, high lipid group 20 and Tong XinLuo group 20. HE Staining and immunohistochemical analysis (ERK 1 and ERK 2) and Western Blot (ERK 1 and ERK 2) and blood biochemical tests (TG TC HDL C LDL C ET 1 NO) were done to evaluate the influence of MAPK on the proliferation of vascular intimal after PTA and the inhibition effect of Tong XinLuo. Using MET 1aMorph Image System to analysis all the materials acquired. Results It showed that Tong XinLuo group had larger lumen area (LA) and smaller neointimal area (NIA) than that of control group and high lipid group, Tong XinLuo group had lower level of serum TC LDL C and endothelin (ET 1) than high lipid group, but higher level of serum NO. Immunohistochemical analysis and Western Blot showed that the expressing of MAPK were increasing after PTA in high lipid group, but decreasing in Tong XinLuo group. Conclusion Tong XinLuo could inhibit the proliferation of intimal after PTA in atherosclerotic rabbit through inhibiting the expressing of MAPK." @default.
- W2387189601 created "2016-06-24" @default.
- W2387189601 creator A5087731845 @default.
- W2387189601 date "2003-01-01" @default.
- W2387189601 modified "2023-09-23" @default.
- W2387189601 title "Effect and mechanism of Tong XinLuo on the expressing of mitogen-activated protein kinases after percutaneous transluminal angioplasty in atherosclerosis rabbit" @default.
- W2387189601 hasPublicationYear "2003" @default.
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